LRP4, A NOVEL RECEPTOR FOR DICKKOPF 1 AND SCLEROSTIN, IS EXPRESSED BY OSTEOBLASTS AND REGULATES BONE GROWTH AND TURNOVER IN VIVO.

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development.For example, Lrp4 binds Wise, a secreted Wnt modulator and BMP antagonist.Lrp4 shares structural elements within the extracellular ligand binding domain with Lrp5 and Lrp6, two established Wnt

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Parametric pattern selection in a reaction-diffusion model.

We compare spot patterns generated by Turing mechanisms with those generated by replication cascades, in a model one-dimensional reaction-diffusion system.We determine the stability region of spot solutions in parameter space as a function of a natural control parameter (feed-rate) where degenerate Tissues patterns with different numbers of spots c

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SS-DBSCAN: Semi-Supervised Density-Based Spatial Clustering of Applications With Noise for Meaningful Clustering in Diverse Density Data

DBSCAN (Density-Based Spatial Clustering of Applications with Noise) is an unsupervised clustering algorithm designed to identify clusters of various shapes and sizes in noisy datasets by pinpointing core points.The primary challenges associated with the DBSCAN algorithm involve the recognition of meaningful clusters within varying densities datase

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